Interactions between hERG and KCNQ1 α-subunits are mediated by their COOH termini and modulated by cAMP

KCNQ1 and hERG encode the voltage-gated potassium channel α-subunits of the cardiac repolarizing currents I(Ks) and I(Kr), respectively. These currents function in vivo with some redundancy to maintain appropriate action potential durations (APDs), and loss-of-function mutations in these channels ma...

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Autores principales: Organ-Darling, Louise E., Vernon, Amanda N., Giovanniello, Jacqueline R., Lu, Yichun, Moshal, Karni, Roder, Karim, Li, Weiyan, Koren, Gideon
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2013
Materias:
Cardiac Excitation and Contraction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566482/
https://ncbi.nlm.nih.gov/pubmed/23241319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00385.2012
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