Pore mutants of HERG and KvLQT1 downregulate the reciprocal currents in stable cell lines

We previously reported a transgenic rabbit model of long QT syndrome based on overexpression of pore mutants of repolarizing K(+) channels KvLQT1 (LQT1) and HERG (LQT2).The transgenes in these rabbits eliminated the slow and fast components of the delayed rectifier K(+) current (I(Ks) and I(Kr), res...

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Main Authors: Ren, Xiao-Qin, Liu, Gong Xin, Organ-Darling, Louise E., Zheng, Renjian, Roder, Karim, Jindal, Hitesh K., Centracchio, Jason, McDonald, Thomas V., Koren, Gideon
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993209/
https://ncbi.nlm.nih.gov/pubmed/20833965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00479.2009
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