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Pore mutants of HERG and KvLQT1 downregulate the reciprocal currents in stable cell lines
We previously reported a transgenic rabbit model of long QT syndrome based on overexpression of pore mutants of repolarizing K(+) channels KvLQT1 (LQT1) and HERG (LQT2).The transgenes in these rabbits eliminated the slow and fast components of the delayed rectifier K(+) current (I(Ks) and I(Kr), res...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
American Physiological Society
2010
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2993209/ https://ncbi.nlm.nih.gov/pubmed/20833965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00479.2009 |
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