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Computational modelling of T-cell formation kinetics: output regulated by initial proliferation-linked deferral of developmental competence

Bone-marrow-derived progenitors must continually enter the thymus of an adult mouse to sustain T-cell homeostasis, yet only a few input cells per day are sufficient to support a yield of 5 × 10(7) immature T-cells per day and an eventual output of 1–2 × 10(6) mature cells per day. While substantial...

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Main Authors: Manesso, Erica, Chickarmane, Vijay, Kueh, Hao Yuan, Rothenberg, Ellen V., Peterson, Carsten
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565808/
https://ncbi.nlm.nih.gov/pubmed/23152106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2012.0774
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