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A Computational Model for Understanding Stem Cell, Trophectoderm and Endoderm Lineage Determination

BACKGROUND: Recent studies have associated the transcription factors, Oct4, Sox2 and Nanog as parts of a self-regulating network which is responsible for maintaining embryonic stem cell properties: self renewal and pluripotency. In addition, mutual antagonism between two of these and other master re...

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Detalhes bibliográficos
Main Authors: Chickarmane, Vijay, Peterson, Carsten
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566811/
https://ncbi.nlm.nih.gov/pubmed/18941526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003478
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