Irreversibility of T-Cell Specification: Insights from Computational Modelling of a Minimal Network Architecture

BACKGROUND/OBJECTIVES: A cascade of gene activations under the control of Notch signalling is required during T-cell specification, when T-cell precursors gradually lose the potential to undertake other fates and become fully committed to the T-cell lineage. We elucidate how the gene/protein dynamic...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Manesso, Erica, Kueh, Hao Yuan, Freedman, George, Rothenberg, Ellen V., Peterson, Carsten
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995000/
https://ncbi.nlm.nih.gov/pubmed/27551921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161260
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