Irreversibility of T-Cell Specification: Insights from Computational Modelling of a Minimal Network Architecture

BACKGROUND/OBJECTIVES: A cascade of gene activations under the control of Notch signalling is required during T-cell specification, when T-cell precursors gradually lose the potential to undertake other fates and become fully committed to the T-cell lineage. We elucidate how the gene/protein dynamic...

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Publicat a:PLoS One
Autors principals: Manesso, Erica, Kueh, Hao Yuan, Freedman, George, Rothenberg, Ellen V., Peterson, Carsten
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995000/
https://ncbi.nlm.nih.gov/pubmed/27551921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161260
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