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Computational modelling of T-cell formation kinetics: output regulated by initial proliferation-linked deferral of developmental competence
Bone-marrow-derived progenitors must continually enter the thymus of an adult mouse to sustain T-cell homeostasis, yet only a few input cells per day are sufficient to support a yield of 5 × 10(7) immature T-cells per day and an eventual output of 1–2 × 10(6) mature cells per day. While substantial...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Royal Society
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3565808/ https://ncbi.nlm.nih.gov/pubmed/23152106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2012.0774 |
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