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On the binding affinity of macromolecular interactions: daring to ask why proteins interact

Interactions between proteins are orchestrated in a precise and time-dependent manner, underlying cellular function. The binding affinity, defined as the strength of these interactions, is translated into physico-chemical terms in the dissociation constant (K(d)), the latter being an experimental me...

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Detalhes bibliográficos
Main Authors: Kastritis, Panagiotis L., Bonvin, Alexandre M. J. J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565702/
https://ncbi.nlm.nih.gov/pubmed/23235262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2012.0835
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