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Spring-Loaded Mechanism of DNA Unwinding by Heptitis C Virus NS3 Helicase

NS3 is an essential helicase for replication of Hepatitis C virus, and is a model enzyme for investigating helicase function. Using single molecule fluorescence analysis, we show that NS3 unwinds DNA in discrete steps of approximately 3-bp. Dwell time analysis indicates that about three hidden steps...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Myong, Sua, Bruno, Michael M., Pyle, Anna M., Ha, Taekjip
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2007
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565428/
https://ncbi.nlm.nih.gov/pubmed/17656723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1144130
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