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Dynamic Origins of Differential RNA Binding Function in Two dsRBDs from the miRNA “Microprocessor” Complex

MicroRNAs (miRNAs) affect gene regulation by base pairing with mRNA and contribute to the control of cellular homeostasis. The first step in miRNA maturation is conducted in the nucleus by the “microprocessor” complex made up of an RNase III enzyme, Drosha, that contains one dsRNA binding domain (ds...

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Autors principals: Wostenberg, Christopher, Quarles, Kaycee A., Showalter, Scott A.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565223/
https://ncbi.nlm.nih.gov/pubmed/21073201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1015716
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