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Ensemble Analysis of Primary miRNA Structure Reveals an Extensive Capacity to Deform near the Drosha Cleavage Site

Most non-coding RNAs function properly only when folded into complex 3D structures, but the experimental determination of these structures remains challenging. Understanding of primary miRNA maturation is currently limited by a lack of solved structures for non-processed forms of the RNA. SHAPE chem...

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Detalhes bibliográficos
Main Authors: Quarles, Kaycee A., Sahu, Debashish, Havens, Mallory A., Forsyth, Ellen R., Wostenberg, Christopher, Hastings, Michelle L., Showalter, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565094/
https://ncbi.nlm.nih.gov/pubmed/23305493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301452a
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