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Back to the future: revisiting HIV-1 lethal mutagenesis

The concept of eliminating HIV-1 infectivity by elevating the viral mutation rate was first proposed over a decade ago, even though the general concept had been conceived earlier for RNA viruses. Lethal mutagenesis was originally viewed as a novel chemotherapeutic approach for treating HIV-1 infecti...

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Bibliografiske detaljer
Main Authors: Dapp, Michael J., Patterson, Steven E., Mansky, Louis M.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565075/
https://ncbi.nlm.nih.gov/pubmed/23195922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tim.2012.10.006
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