The Kinase PDK1 Is Essential for B-Cell Receptor Mediated Survival Signaling

Phosphoinositide-dependent kinase 1 (PDK1) plays an important role in integrating the T cell antigen receptor (TCR) and CD28 signals to achieve efficient NF-κB activation. PDK1 is also an important regulator of T cell development, mediating pre-TCR induced proliferation signals. However, the role of...

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Main Authors: Park, Sung-Gyoo, Long, Meixiao, Kang, Jung-Ah, Kim, Woo-Seok, Lee, Cho-Rong, Im, Sin-Hyeog, Strickland, Ian, Schulze-Luehrmann, Jan, Hayden, Matthew S., Ghosh, Sankar
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564844/
https://ncbi.nlm.nih.gov/pubmed/23393571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055378
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