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Transition from heterotypic to homotypic PDK1 homodimerization is essential for TCR-mediated NF-κB activation
Strong NF-κB activation requires ligation of both the CD28 co-receptor and TCR. PDK1 acts as a scaffold by binding both PKCθ and CARMA1 and is therefore essential for signaling to NF-κB. Here, we demonstrate the importance of PDK1 threonine (Thr)-513 phosphorylation in regulating the intermolecular...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3664235/ https://ncbi.nlm.nih.gov/pubmed/23530144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202923 |
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