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PDK1 is required for maintenance of CD4+ FoxP3+ regulatory T cell function
Regulatory T (Treg) cells have an essential role in maintaining immune homeostasis, in part by suppressing effector T (Teff) cell functions. Phosphoinositide-dependent kinase 1 (PDK1) is a pleiotropic kinase that acts as a key effector downstream of phosphatidylinositol-3-OH kinase (PI3K) in many ce...
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| Gepubliceerd in: | J Immunol |
|---|---|
| Hoofdauteurs: | , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2021
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8026672/ https://ncbi.nlm.nih.gov/pubmed/33789982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000051 |
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