PDK1 is required for maintenance of CD4+ FoxP3+ regulatory T cell function

Regulatory T (Treg) cells have an essential role in maintaining immune homeostasis, in part by suppressing effector T (Teff) cell functions. Phosphoinositide-dependent kinase 1 (PDK1) is a pleiotropic kinase that acts as a key effector downstream of phosphatidylinositol-3-OH kinase (PI3K) in many ce...

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Publicado no:J Immunol
Main Authors: Oh, Hyunju, Zhao, Jingyao, Grinberg-Bleyer, Yenkel, Postler, Thomas S., Wang, Pingzhang, Park, Sung-Gyoo, Rabadan, Raul, Hayden, Matthew S., Ghosh, Sankar
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026672/
https://ncbi.nlm.nih.gov/pubmed/33789982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000051
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