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Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet–associated endoplasmic reticulum membranes
Sterol-induced binding to Insigs in endoplasmic reticulum (ER) membranes triggers ubiquitination of the cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl CoA reductase. This ubiquitination, which is mediated by Insig-associated ubiquitin ligases gp78 and Trc8, is obligatory for extraction o...
में बचाया:
मुख्य लेखकों: | , , |
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स्वरूप: | Artigo |
भाषा: | Inglês |
प्रकाशित: |
The American Society for Cell Biology
2013
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विषय: | |
ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3564538/ https://ncbi.nlm.nih.gov/pubmed/23223569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-07-0564 |
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