Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet–associated endoplasmic reticulum membranes

Sterol-induced binding to Insigs in endoplasmic reticulum (ER) membranes triggers ubiquitination of the cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl CoA reductase. This ubiquitination, which is mediated by Insig-associated ubiquitin ligases gp78 and Trc8, is obligatory for extraction o...

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Bibliographic Details
Main Authors: Jo, Youngah, Hartman, Isamu Z., DeBose-Boyd, Russell A.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2013
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564538/
https://ncbi.nlm.nih.gov/pubmed/23223569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-07-0564
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