Alterations of Retinal Vasculature in Cystathionine-Beta-Synthase Mutant Mice, a Model of Hyperhomocysteinemia

PURPOSE. Mice with moderate/severe hyperhomocysteinemia due to deficiency or absence of the cbs gene encoding cystathionine-beta-synthase (CBS) have marked retinal disruption, ganglion cell loss, optic nerve mitochondrial dysfunction, and ERG defects; those with mild hyperhomocysteinemia have delaye...

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Main Authors: Tawfik, Amany, Al-Shabrawey, Mohamed, Roon, Penny, Sonne, Srinivas, Covar, Jason A., Matragoon, Surapoon, Ganapathy, Preethi S., Atherton, Sally S., El-Remessy, Azza, Ganapathy, Vadivel, Smith, Sylvia B.
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564451/
https://ncbi.nlm.nih.gov/pubmed/23307965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-10536
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