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Pathogenic prions deviate PrP(C) signaling in neuronal cells and impair A-beta clearance
The subversion of the normal function exerted by the cellular prion protein (PrP(C)) in neurons by pathogenic prions is assumed to have a central role in the pathogenesis of transmissible spongiform encephalopathies. Using two murine models of prion infection, the 1C11 neuronal cell line and neurosp...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3563983/ https://ncbi.nlm.nih.gov/pubmed/23303130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.195 |
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