Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression and improves chemotherapeutic responses

Tumor-infiltrating immune cells can promote chemoresistance and metastatic spread in aggressive tumors. Consequently, the type and quality of immune responses present in the neoplastic stroma are highly predictive of patient outcome in several cancer types. In addition to host immune responses, intr...

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Detalhes bibliográficos
Main Authors: Mitchem, Jonathan B., Brennan, Donal J., Knolhoff, Brett L., Belt, Brian A., Zhu, Yu, Sanford, Dominic E., Belaygorod, Larisa, Carpenter, Danielle, Collins, Lynne, Piwnica-Worms, David, Hewitt, Stephen, Udupi, Girish Mallya, Gallagher, William M., Wegner, Craig, West, Brian L., Wang-Gillam, Andrea, Goedegebuure, S Peter, Linehan, David C., DeNardo, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563931/
https://ncbi.nlm.nih.gov/pubmed/23221383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2731
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