CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T Cell Checkpoint Immunotherapy in Pancreatic Cancer Models

Cancer immunotherapy generally offers limited clinical benefit without coordinated strategies to mitigate the immunosuppressive nature of the tumor microenvironment. Critical drivers of immune escape in the tumor microenvironment include tumor-associated macrophages (TAM) and myeloid-derived suppres...

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Detalhes bibliográficos
Main Authors: Zhu, Yu, Knolhoff, Brett L., Meyer, Melissa A., Nywening, Timothy M., West, Brian L., Luo, Jingqin, Wang-Gillam, Andrea, Goedegebuure, S Peter, Linehan, David C., DeNardo, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182950/
https://ncbi.nlm.nih.gov/pubmed/25082815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3723
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