CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T Cell Checkpoint Immunotherapy in Pancreatic Cancer Models

Cancer immunotherapy generally offers limited clinical benefit without coordinated strategies to mitigate the immunosuppressive nature of the tumor microenvironment. Critical drivers of immune escape in the tumor microenvironment include tumor-associated macrophages (TAM) and myeloid-derived suppres...

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Bibliografische gegevens
Hoofdauteurs: Zhu, Yu, Knolhoff, Brett L., Meyer, Melissa A., Nywening, Timothy M., West, Brian L., Luo, Jingqin, Wang-Gillam, Andrea, Goedegebuure, S Peter, Linehan, David C., DeNardo, David G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182950/
https://ncbi.nlm.nih.gov/pubmed/25082815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3723
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