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Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions

BACKGROUND: Cancer, much like most human disease, is routinely studied by utilizing model organisms. Of these model organisms, mice are often dominant. However, our assumptions of functional equivalence fail to consider the opportunity for divergence conferred by ~180 Million Years (MY) of independe...

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Podrobná bibliografie
Hlavní autoři: Morgan, Claire C, Shakya, Kabita, Webb, Andrew, Walsh, Thomas A, Lynch, Mark, Loscher, Christine E, Ruskin, Heather J, O’Connell, Mary J
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563467/
https://ncbi.nlm.nih.gov/pubmed/22788692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-12-114
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