Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions

BACKGROUND: Cancer, much like most human disease, is routinely studied by utilizing model organisms. Of these model organisms, mice are often dominant. However, our assumptions of functional equivalence fail to consider the opportunity for divergence conferred by ~180 Million Years (MY) of independe...

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Main Authors: Morgan, Claire C, Shakya, Kabita, Webb, Andrew, Walsh, Thomas A, Lynch, Mark, Loscher, Christine E, Ruskin, Heather J, O’Connell, Mary J
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563467/
https://ncbi.nlm.nih.gov/pubmed/22788692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-12-114
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