Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions

BACKGROUND: Cancer, much like most human disease, is routinely studied by utilizing model organisms. Of these model organisms, mice are often dominant. However, our assumptions of functional equivalence fail to consider the opportunity for divergence conferred by ~180 Million Years (MY) of independe...

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Detalhes bibliográficos
Main Authors: Morgan, Claire C, Shakya, Kabita, Webb, Andrew, Walsh, Thomas A, Lynch, Mark, Loscher, Christine E, Ruskin, Heather J, O’Connell, Mary J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563467/
https://ncbi.nlm.nih.gov/pubmed/22788692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-12-114
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