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Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels

Small- and intermediate-conductance Ca(2+)-activated potassium channels, activated by Ca(2+)-bound calmodulin, play an important role in regulating membrane excitability. These channels are also linked to clinical abnormalities. A tremendous amount of effort has been devoted to developing small mole...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhang, Miao, Pascal, John M., Schumann, Marcel, Armen, Roger S., Zhang, Ji-fang
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563359/
https://ncbi.nlm.nih.gov/pubmed/22929778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2017
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