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Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels
Small- and intermediate-conductance Ca(2+)-activated potassium channels, activated by Ca(2+)-bound calmodulin, play an important role in regulating membrane excitability. These channels are also linked to clinical abnormalities. A tremendous amount of effort has been devoted to developing small mole...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3563359/ https://ncbi.nlm.nih.gov/pubmed/22929778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2017 |
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