Regulation of error-prone translesion synthesis by Spartan/C1orf124

Translesion synthesis (TLS) employs low fidelity polymerases to replicate past damaged DNA in a potentially error-prone process. Regulatory mechanisms that prevent TLS-associated mutagenesis are unknown; however, our recent studies suggest that the PCNA-binding protein Spartan plays a role in suppre...

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Autores principales: Kim, Myoung Shin, Machida, Yuka, Vashisht, Ajay A., Wohlschlegel, James A., Pang, Yuan-Ping, Machida, Yuichi J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561950/
https://ncbi.nlm.nih.gov/pubmed/23254330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1267
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