Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance

Unrepaired DNA damage may arrest ongoing replication forks, potentially resulting in fork collapse, increased mutagenesis and genomic instability. Replication through DNA lesions depends on mono- and polyubiquitylation of proliferating cell nuclear antigen (PCNA), which enable translesion synthesis...

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Detalhes bibliográficos
Main Authors: Juhasz, Szilvia, Balogh, David, Hajdu, Ildiko, Burkovics, Peter, Villamil, Mark A., Zhuang, Zhihao, Haracska, Lajos
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510514/
https://ncbi.nlm.nih.gov/pubmed/22987070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks850
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