OSTEOPONTIN, AN OXIDANT STRESS-SENSITIVE CYTOKINE, UP-REGULATES COLLAGEN-I VIA INTEGRIN α(V)β(3) ENGAGEMENT AND PI3K-pAkt-NFκB SIGNALING

BACKGROUND & AIM: A key feature in the pathogenesis of liver fibrosis is fibrillar collagen-I deposition; yet, mediators that could be key therapeutic targets remain elusive. We hypothesized that osteopontin (OPN), an extracellular matrix (ECM) cytokine expressed in hepatic stellate cells (HSC),...

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Autores principales: Urtasun, Raquel, Lopategi, Aritz, George, Joseph, Leung, Tung-Ming, Lu, Yongke, Wang, Xiaodong, Ge, Xiaodong, Fiel, Maria Isabel, Nieto, Natalia
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561739/
https://ncbi.nlm.nih.gov/pubmed/21953216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24701
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