Access to the Nucleus and Functional Association with c-Myc Is Required for the Full Oncogenic Potential of ΔEGFR/EGFRvIII

ΔEGFR is a potent glioblastoma oncogene which has been studied primarily as a plasma membrane kinase. Using intracranial xenograft studies in mice, we show that blocking ΔEGFR access to the nucleus attenuates its tumorigenicity and, conversely, that promoting nuclear accumulation enhances this, prov...

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Main Authors: Gururaj, Anupama E., Gibson, Laura, Panchabhai, Sonali, Bai, MingHui, Manyam, Ganiraju, Lu, Yue, Latha, Khatri, Rojas, Marta L., Hwang, Yeohyeon, Liang, Shoudan, Bogler, Oliver
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561561/
https://ncbi.nlm.nih.gov/pubmed/23250739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.399352
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