Role of Cathepsin D in U18666A-induced Neuronal Cell Death: POTENTIAL IMPLICATION IN NIEMANN-PICK TYPE C DISEASE PATHOGENESIS

Cathepsin D is an aspartyl protease that plays a crucial role in normal cellular functions and in a variety of neurodegenerative disorders, including Niemann-Pick type C (NPC) disease, which is characterized by intracellular accumulation of cholesterol and glycosphingolipids in many tissues, includi...

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Detalhes bibliográficos
Main Authors: Amritraj, Asha, Wang, Yanlin, Revett, Timothy J., Vergote, David, Westaway, David, Kar, Satyabrata
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561536/
https://ncbi.nlm.nih.gov/pubmed/23250759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.412460
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