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Hyperactivation of the Mammalian Degenerin MDEG Promotes Caspase-8 Activation and Apoptosis

Intracellular calcium overload plays a critical role in numerous pathological syndromes such as heart failure, brain ischemia, and stroke. Hyperactivation of the acid-sensing ion channels including degenerin/epithelial amiloride-sensitive sodium (DEG/ENaC) channels has been shown to elevate intracel...

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Detalhes bibliográficos
Main Authors: Pan, Ji-An, Fan, Yongjun, Gandhirajan, Rajesh Kumar, Madesh, Muniswamy, Zong, Wei-Xing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561519/
https://ncbi.nlm.nih.gov/pubmed/23239879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.441063
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