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Activation of Caspase-9, but Not Caspase-2 or Caspase-8, Is Essential for Heat-induced Apoptosis in Jurkat Cells

Exposure of cells to hyperthermia is known to induce apoptosis, although the underlying mechanisms are only partially understood. Here, we examine the molecular requirements necessary for heat-induced apoptosis using genetically modified Jurkat T-lymphocytes. Cells stably overexpressing Bcl-2/Bcl-x(...

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Bibliografske podrobnosti
Main Authors: Shelton, Shary N., Dillard, Cindy D., Robertson, John D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003351/
https://ncbi.nlm.nih.gov/pubmed/20978129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167635
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