Adenylate Cyclase Toxin from Bordetella pertussis Synergizes with Lipopolysaccharide To Promote Innate Interleukin-10 Production and Enhances the Induction of Th2 and Regulatory T Cells

Adenylate cyclase toxin (CyaA) from Bordetella pertussis can subvert host immune responses allowing bacterial colonization. Here we have examined its adjuvant and immunomodulatory properties and the possible contribution of lipopolysaccharide (LPS), known to be present in purified CyaA preparations....

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Detalhes bibliográficos
Main Authors: Ross, Pádraig J., Lavelle, Ed C., Mills, Kingston H. G., Boyd, Aoife P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC356053/
https://ncbi.nlm.nih.gov/pubmed/14977963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.3.1568-1579.2004
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