Proteolytic processing of the prion protein in health and disease

A variety of physiological functions, not only restricted to the nervous system, are discussed for the cellular prion protein (PrP(C)). A prominent, non-physiological property of PrPC is the conversion into its pathogenic isoform (PrP(Sc)) during fatal, transmissible, and neurodegenerative prion dis...

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Bibliographic Details
Main Authors: Altmeppen, Hermann C, Puig, Berta, Dohler, Frank, Thurm, Dana K, Falker, Clemens, Krasemann, Susanne, Glatzel, Markus
Format: Artigo
Language:Inglês
Published: e-Century Publishing Corporation 2012
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3560451/
https://ncbi.nlm.nih.gov/pubmed/23383379
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