Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides

The effects of reducing the molecular weight of the antileishmanial compound DB766 on DNA binding affinity, antileishmanial activity and cytotoxicity are reported. The bis-arylimidamides were prepared by the coupling of aryl S-(2-naphthylmethyl)thioimidates with the corresponding amines. Specificall...

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Detalhes bibliográficos
Main Authors: Banerjee, Moloy, Farahat, Abdelbasset A., Kumar, Arvind, Wenzler, Tanja, Brun, Reto, Munde, Manoj M., Wilson, W. David, Zhu, Xiaohua, Werbovetz, Karl A., Boykin, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3560421/
https://ncbi.nlm.nih.gov/pubmed/22840696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.06.058
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