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DNA interstrand crosslink repair and cancer
Interstrand crosslinks (ICLs) are highly toxic DNA lesions that prevent transcription and replication by inhibiting DNA strand separation. Agents that induce ICLs were one of the earliest, and are still the most widely used, forms of chemotherapeutic drug. Only recently, however, have we begun to un...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3560328/ https://ncbi.nlm.nih.gov/pubmed/21701511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc3088 |
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