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Helios induces epigenetic silencing of Il2 gene expression in regulatory T cells
Regulatory T cells play a critical role in maintaining immune tolerance and preventing autoimmune disease. Treg cells express the transcription factor Foxp3, which acts as a master regulator of their differentiation and controls their capacity to suppress T cell responses. Treg cells have an intrins...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3558938/ https://ncbi.nlm.nih.gov/pubmed/23275607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200792 |
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