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RBCK1, an E3 Ubiquitin Ligase, Interacts with and Ubiquinates the Human Pregnane X Receptor
The pregnane X receptor (PXR, NR1I2) plays a pivotal role in the disposition and detoxification of numerous foreign and endogenous chemicals by increasing transcription of numerous target genes, including phase I and II drug-metabolizing enzymes and transporters. In the present study, yeast two-hybr...
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Main Authors: | , , , |
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Format: | Artigo |
Jezik: | Inglês |
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The American Society for Pharmacology and Experimental Therapeutics
2013
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3558864/ https://ncbi.nlm.nih.gov/pubmed/23160820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.048728 |
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