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RBCK1, an E3 Ubiquitin Ligase, Interacts with and Ubiquinates the Human Pregnane X Receptor

The pregnane X receptor (PXR, NR1I2) plays a pivotal role in the disposition and detoxification of numerous foreign and endogenous chemicals by increasing transcription of numerous target genes, including phase I and II drug-metabolizing enzymes and transporters. In the present study, yeast two-hybr...

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Main Authors: Rana, Ritu, Coulter, Sherry, Kinyamu, Harriet, Goldstein, Joyce A.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558864/
https://ncbi.nlm.nih.gov/pubmed/23160820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.048728
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