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NOD-scid IL2R γ(null) mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways

BACKGROUND: Animal models of human inflammatory diseases have limited predictive quality for human clinical trials for various reasons including species specific activation mechanisms and the immunological background of the animals which markedly differs from the genetically heterogeneous and often...

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Bibliografische gegevens
Hoofdauteurs: Zadeh-Khorasani, Maryam, Nolte, Thomas, Mueller, Thomas D, Pechlivanis, Markos, Rueff, Franziska, Wollenberg, Andreas, Fricker, Gert, Wolf, Eckhard, Siebeck, Matthias, Gropp, Roswitha
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558457/
https://ncbi.nlm.nih.gov/pubmed/23294516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-4
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