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Participation of the Ubiquitin-Conjugating Enzyme UBE2E3 in Nedd4-2-Dependent Regulation of the Epithelial Na(+) Channel

The epithelial Na(+) channel (ENaC) is a heteromeric protein complex playing a fundamental role in Na(+) homeostasis and blood pressure regulation. Specific mutations inactivating PY motifs in ENaC C termini cause Liddle's syndrome, an inherited form of hypertension. Previously we showed that t...

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Pubblicato in:Mol Cell Biol
Autori principali: Debonneville, Christophe, Staub, Olivier
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2004
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC355826/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14993279/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.6.2397-2409.2004
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