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Intramolecular carbolithiation of N-allyl-ynamides: an efficient entry to 1,4-dihydropyridines and pyridines – application to a formal synthesis of sarizotan

We have developed a general synthesis of polysubstituted 1,4-dihydropyridines and pyridines based on a highly regioselective lithiation/6-endo-dig intramolecular carbolithiation from readily available N-allyl-ynamides. This reaction, which has been successfully applied to the formal synthesis of the...

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Detalhes bibliográficos
Main Authors: Gati, Wafa, Rammah, Mohamed M, Rammah, Mohamed B, Evano, Gwilherm
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557957/
https://ncbi.nlm.nih.gov/pubmed/23365632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.8.250
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