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Harnessing the Electrophilicity of Keteniminium Ions: A Simple and Straightforward Entry to Tetrahydropyridines and Piperidines from Ynamides

An efficient, modular and straightforward entry to tetrahydropyridines and piperidines is reported. This reaction is based on a formal intramolecular hydroalkylation of readily available, properly substituted ynamides which, upon simple activation under acidic conditions, generate highly reactive ac...

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Pubblicato in:Angew Chem Int Ed Engl
Autori principali: Lecomte, Morgan, Evano, Gwilherm
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069598/
https://ncbi.nlm.nih.gov/pubmed/26934474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201510729
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