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Alkylation induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins
O(6)-methylguanine DNA methyltransferase (MGMT) suppresses mutations and cell death that result from alkylation damage. MGMT expression is lost by epigenetic silencing in a variety of human cancers including nearly half of sporadic colorectal cancers, suggesting that this loss maybe causal. Using mi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557788/ https://ncbi.nlm.nih.gov/pubmed/19029948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.426 |
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