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Functions of the 19S Complex in Proteasomal Degradation
The 26S proteasome degrades ubiquitylated proteins. It consists of the 20S proteasome and the PA700/19S complex. PA700 plays essential roles in processing ubiquitylated substrates; it can bind, deubiquitylate, and unfold ubiquitylated proteins, which then translocate into the proteolytic chamber of...
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| Glavni autori: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557657/ https://ncbi.nlm.nih.gov/pubmed/23290100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2012.11.009 |
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