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Functions of the 19S Complex in Proteasomal Degradation

The 26S proteasome degrades ubiquitylated proteins. It consists of the 20S proteasome and the PA700/19S complex. PA700 plays essential roles in processing ubiquitylated substrates; it can bind, deubiquitylate, and unfold ubiquitylated proteins, which then translocate into the proteolytic chamber of...

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Bibliografske podrobnosti
Main Authors: Liu, Chang-Wei, Jacobson, Andrew D.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557657/
https://ncbi.nlm.nih.gov/pubmed/23290100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2012.11.009
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