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Phase I study of troxacitabine administered by continuous infusion in subjects with advanced solid malignancies
BACKGROUND: Troxacitabine is a novel L-nucleoside analogue. Preclinical studies showed improved activity with infusions of at least 3 days compared with bolus regimens, especially at concentrations >20 ng/ml. This phase I study tested the feasibility of achieving a troxacitabine steady-state conc...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557502/ https://ncbi.nlm.nih.gov/pubmed/18245131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdm572 |
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