Integrated preclinical and clinical development of S-trans, trans-farnesylthiosalicylic acid (FTS, Salirasib) in pancreatic cancer

PURPOSE: S-trans,trans-Farnesylthiosalicylic Acid (FTS, salirasib) inhibits Ras-dependent cell growth by dislodging all isoforms of Ras, including mutant Ras, from the plasma membrane. This study evaluated the activity, safety, and toxicity of salirasib in preclinical models and patients with metast...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Laheru, Daniel, Shah, Preeti, Rajeshkumar, N. V., McAllister, Florencia, Taylor, Gretchen, Goldsweig, Howard, Le, Dung T., Donehower, Ross, Jimeno, Antonio, Linden, Sheila, Zhao, Ming, Song, Dongweon, Rudek, Michelle A., Hidalgo, Manuel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557459/
https://ncbi.nlm.nih.gov/pubmed/22547163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-012-9818-6
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