Treatment of MRL/lpr mice, a genetic autoimmune model, with the Ras inhibitor, farnesylthiosalicylate (FTS)

Activation and proliferation of lymphocytes requires the active signal transducer Ras. Activation of lymphocytes, associated with autoimmunity, may therefore be modified by S-farnesylthiosalicylic acid (FTS), a synthetic substance that detaches Ras from the inner cell membrane and induces its rapid...

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Detalhes bibliográficos
Main Authors: Katzav, A, Kloog, Y, Korczyn, A D, Niv, H, Karussis, D M, Wang, N, Rabinowitz, R, Blank, M, Shoenfeld, Y, Chapman, J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
Assuntos:
Rheumatic Disease/Vasculitis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906212/
https://ncbi.nlm.nih.gov/pubmed/11737078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2001.01674.x
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