Treatment of MRL/lpr mice, a genetic autoimmune model, with the Ras inhibitor, farnesylthiosalicylate (FTS)

Activation and proliferation of lymphocytes requires the active signal transducer Ras. Activation of lymphocytes, associated with autoimmunity, may therefore be modified by S-farnesylthiosalicylic acid (FTS), a synthetic substance that detaches Ras from the inner cell membrane and induces its rapid...

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Bibliografiske detaljer
Main Authors: Katzav, A, Kloog, Y, Korczyn, A D, Niv, H, Karussis, D M, Wang, N, Rabinowitz, R, Blank, M, Shoenfeld, Y, Chapman, J
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2001
Fag:
Rheumatic Disease/Vasculitis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906212/
https://ncbi.nlm.nih.gov/pubmed/11737078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2001.01674.x
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